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KMID : 0363620070280030261
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 3 p.261 ~ p.272
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The effect of Acanthopanax sessiliflorus using the model of neuropathic pain and formalin-induced pain.
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Kim Jang-Hyun
Chang Gyu-Tae
Kang Mi-Sun
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Abstract
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Objective : This study was conducted to determine the analgesic effect of Acanthopanax sessiliflorus using the model of neuropathic pain and formalin-induced pain.
Methods : A model of neuropathic pain was made by injuring the tibial nerve and sural nerve while the common peroneal nerve was maintained. After 2 weeks, the Acanthopanax sessiliflorus was orally administered to rats. The author performed behavioral teststo try out mechanical allodynia using von frey filament and cold allodynia using acetone, which are calculated by counting withdrawal response on foot. Thirty minutes after the Acanthopanax sessiliflorus injection in the abdominal cavity, the formalin test was performed. 2% formalin in a volume of 20{mu}lwas injected subcutaneously into the plantar surface of the hindpaw with 26-G needle. To access formalin-induced pain behavior, paw licking time was measured every 5 min.
Results : The Acanthopanax sessiliflorus 400mg/10ml/kg group showed significant decrease the withdrawal response of mechanical allodynia using von frey filament in the 10min, 30min, 60min and 120min increments compared with the control group. There were no significant differences in each group in the withdrawal response of cold allodynia using acetone. The Acanthopanax sessiliflorus group showed significant decrease in the formalin-induced pain behavior in the 15min, 20min and 25min increments compared with the control group.
Conclusion : The Acanthopanax sessiliflorus may have a significant analgesic effect on the general pain as well as nerve injury pain.
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KEYWORD
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Acanthopanax sessiliflorus, neuropathic pain, formalin-induced pain
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